ガスクロマトグラフィーによるナルコチンおよびパパベリンの熱分解生成物に関する研究

吉村 実, 出来 三男

doi:10.2116/bunsekikagaku.12.941

ガスクロマトグラフィーによるナルコチンおよびパパベリンの熱分解生成物に関する研究

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吉村実

長崎大学薬学部
出来三男

長崎税関

書誌事項

タイトル別名

Studies on thermal degradation of narcotine and papaverine by gaschromatography
ガスクロマトグラフィーニヨルナルコチンオヨビパパベリンノネツブンカイセイセイブツニカンスルケンキュウ

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説明

The thermal degradation products of narcotine and papaverine are separated by gaschromatography. The column is packed with Diasolid L impregnated with polyethylene glycol 6, 000. The columns employed are 2 m or 3 m in length ; they are used at 65°C for low-boiling products, and at 200°C for high boiling products.<BR>Thermal degradation products of narcotine or papaverine are fractionated into two portions ; the one is readily volatile products absorbed in ethanol, and the other is high-boiling matters dissolving in ethanol-acetone (1 : 1, v/v).<BR>Trimethylamine, dimethylamine and methanol are isolated from the mixture of low boiling products of narcotine decomposed at 220°C to 350°C, while monomethylamine and methanol are obtained from papaverine decomposed at 300°C to 350°C.<BR>Veratrol, guaiacol, homoveratrol and creosol are detected in high-boiling fractions from both samples although piperonal and veratric aldehyde are obtained only from narcotine.