The clinical examination of 50% glucose solution pleurodesis in patients with pneumothorax, lung resection, and malignant pleural effusion

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  • Togo Takeo
    Department of Thoracic Surgery, Sendai Medical Center Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University
  • Hasumi Tohru
    Department of Thoracic Surgery, Sendai Medical Center
  • Hoshi Fumihiko
    Department of Thoracic Surgery, Sendai Medical Center Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University
  • Kikuchi Naohiko
    Department of Thoracic Surgery, Sendai Medical Center
  • Okada Yoshinori
    Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University
  • Saito Yasuki
    Department of Thoracic Surgery, Sendai Medical Center

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Other Title
  • 気胸，術後肺瘻，癌性胸水における50%ブドウ糖液を用いた胸膜癒着術の検討

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<p>We analyzed the effect of pleurodesis with a 50% glucose solution on patients with pneumothorax, pulmonary air leakage after lung resection, and malignant pleural effusion. Twenty-one male and 8 female patients aged 61.0 on average were injected with 200 mL of a 50% glucose solution into the pleural cavity, and 2 patients were injected with 100 mL of the solution because of their poor performance status. Of the 29 cases receiving 200 mL, 14 involved pneumothorax, 11 involved pulmonary air leakage after lung resection, and 4 involved malignant pleural effusion, including 5 untreated diabetic patients whose HbA1c was 6.7% on average (diabetes mellitus group: DM group). Pleurodesis with a 50% glucose solution was effective for 11 patients with pneumothorax and 9 patients with pulmonary air leakage after lung resection. In most cases, air leakage had disappeared by the first day. Half of the malignant pleural effusion cases were controlled. The 2 cases treated with 100 mL of glucose solution showed a smaller drainage volume, with successful results. A significantly higher temporary rise in the blood sugar level was observed in the DM group, but adverse effects were not seen in either the DM or non-DM group. Chest pain and transient fever were observed in many cases, but these were not serious in any patient. In conclusion, pleurodesis with a 50% glucose solution showed significant effectiveness and safety for patients with air leakage due to pulmonary air leakage after lung resection, and efficiency for malignant pleural effusion was also suggested.</p>

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