Thymic carcinoma associated with Sjoegren syndrome, Hashimoto's disease and dermatomyositis; a case report.

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  • Kurisu Sumiho
    Third Department of Surgery, St. Marianna University School of Medicine
  • Osada Hiroaki
    Third Department of Surgery, St. Marianna University School of Medicine
  • Yokote Kumio
    Third Department of Surgery, St. Marianna University School of Medicine
  • Yamate Noboru
    Third Department of Surgery, St. Marianna University School of Medicine

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  • Ｓｊｏｇｒｅｎ症候群・橋本病・皮膚筋炎に合併した胸腺癌の１切除例

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A 73-year-old female who had been treated for Sjögren syndrome and Hashimoto's disease presented with the chief complaint of muscle weakness. The diagnosis was dermatomyositis, and she was examined further for the possible coexistence of a malignant tumor, since that both Sjogren syndrome and dermatomyositis have often been reported to be complicated with a malignant tumor. CT disclosed an anterior mediastinal tumor, which was diagnosed a thymoma. The mass was resected, and thymectomy was also performed. Postoperative pathological examination showed squamous cell carcinoma of the thymus. Intraoperative lymph node dissection was not performed, so postoperative radiation therapy was given, up to a total of 50 Gy. The signs and symptoms of dermatomyositis improved postoperatively, but those of Sjdgren syndrome and Hashimoto's disease did not. The patient is well one year and ten months after operation without any evidence of recurring thymic carcinoma. Detailed examination for possible malignant tumor complicated with an autoimmune disease resulted in successful early resection of thymic cancer. Concomitant extended thymectomy did not, however, remove all the signs and symptons of the autoimmune diseases.

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