Two cases of thymic mucoepidermoid caricinoma showing different clinicopathological features

DOI 26 References
  • Maeda Jun
    Department of Thoracic Surgery Osaka Medical Center for Cancer and Cardiovascular Diseases
  • Higashiyama Masahiko
    Department of Thoracic Surgery Osaka Medical Center for Cancer and Cardiovascular Diseases
  • Oda Kazuyuki
    Department of Thoracic Surgery Osaka Medical Center for Cancer and Cardiovascular Diseases
  • Okami Jiro
    Department of Thoracic Surgery Osaka Medical Center for Cancer and Cardiovascular Diseases
  • Tsukamoto Yoshitane
    Department of Pathology Osaka Medical Center for Cancer and Cardiovascular Diseases
  • Koyama Mitsuhiro
    Department of Diagnostic Radiology Osaka Medical Center for Cancer and Cardiovascular Diseases
  • Kodama Ken
    Department of Thoracic Surgery Osaka Medical Center for Cancer and Cardiovascular Diseases

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  • 分化度の異なる胸腺粘表皮癌２例の臨床病理学的検討

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Abstract

Mucoepidermoid carcinoma of the thymus is rare, accounting for less than 2% of thymic carcinomas, and the treatment strategy has not yet been elucidated. We present two cases of mucoepidermoid carcinoma of histologically low- and high-grade. We encountered a 58-year-old man with high-grade mucoepidermoid carcinoma. Thymectomy with lymph node dissection and intrathoracic chemo-thermotherapy following the operation was carried out. Only six months after the initial treatment, PET-CT scan showed recurrence to the adrenal gland. Eight months after resection, PET-CT scan revealed recurrence to the jejunum. The patient is being treated with systemic chemotherapy. The other case was a 53-year-old man with a low-grade tumor treated with multimodality therapy, as we previously reported. He underwent complete resection, and the specimen revealed low-grade mucoepidermoid carcinoma. However, the tumor recurred to the chest wall and pleura in 57 and 69 months respectively. Therefore, he was treated with re-resection, systemic chemotherapy, intrathoracic chemo-thermotherapy, and irradiation. He died of tumor progression with multiple metastases to the liver, vertebra, spleen, and kidney at 93 months after the initial resection.

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