Inhibitory Effect of Oxovanadium(IV), Copper(II), and Zinc(II) Ions on the Activity of an Alpha-glucosidase from a <I>Saccharomyces sp</I>.

DOI Web Site 28 References
  • Yoshikawa Yutaka
    Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University,
  • Hirata Ryoko
    Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University,
  • Sakurai Hiromu
    Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University,

Bibliographic Information

Other Title
  • Inhibitory Effect of Oxovanadium(IV), Copper(II), and Zinc(II) Ions on the Activity of an Alpha-glucosidase from a Saccharomyces sp

Search this article

Abstract

We investigated the in vitro and in vivo effects of metal ions on the activity of an alpha-glucosidase (Saccharomyces sp.). CuSO4, ZnSO4, and VOSO4 significantly inhibited the alpha-glucosidase activity in vitro. Additionally, we examined their effects on the blood glucose level by performing oral carbohydrate tolerance tests in both normal ddY mice and streptozotocin-induced diabetic mice. After oral administration of these three metal compounds, the elevation in the blood glucose levels in mice administered disaccharide (sucrose) was significantly suppressed in comparison with untreated mice. On the other hand, the elevation in the blood glucose levels in mice administered monosaccharide (glucose) was not suppressed when such compounds or a vehicle was administered. The results suggested that some metal ions suppress disacharide digestion probably due to the inhibition of the alpha-glucosidase activity in the epithelium of the small intestine.

Journal

References(28)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top