Insulinomimetic activity of zinc (II) complexes with halogenated picolinic acids.
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- Yamamoto Shuhei
- Department of Chemistry, Graduate School of Science, Osaka City University
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- Yoshikawa Yutaka
- Department of Chemistry, Graduate School of Science, Osaka City University
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- Ueda Eriko
- Department of Chemistry, Graduate School of Science, Osaka City University
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- Yamashita Tetushi
- Department of Chemistry, Graduate School of Science, Osaka City University
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- Kajiwara Naemi
- Graduate School of Life Science, Kobe Women’s University
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- Sakurai Hiromu
- Department of Analytical and Bioinorganic Chemistry, Kyoto-Pharmaceutical University
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- Kojima Yoshitane
- Department of Chemistry, Graduate School of Science, Osaka City University
Bibliographic Information
- Other Title
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- ハロゲン化ピコリン酸誘導体／亜鉛（ＩＩ）錯体のインスリン様作用
- ハロゲンカ ピコリンサン ユウドウタイ アエン 2 サクタイ ノ インスリン ヨウ サヨウ
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Abstract
We prepared six new zinc(II) complexes of halogenated picolinic acids with a Zn(N2O2) coordination mode and evaluated for their insulinomimetic activities by in vitro study. By introducing an electron withdrawing halogen groups into the picolinic acid, we prepared bis(4- or 6-chloro picolinato), bis(4-, 5- or 6-iodo picolinato), and bis(6-bromo picolinato)/zinc(II) complexes (Zn(4cpa)2, Zn(6cpa)2, Zn(4ipa)2, Zn(5ipa)2, Zn(6ipa)2, and Zn(6bpa)2, respectively). By in vitro evaluation of the inhibition of free fatty acid (FFA) release from isolated rat adipocytes in the presence of epinephrine, the insulinomimetic activities of Zn(4cpa)2, Zn(6cpa)2, Zn(4ipa)2, Zn(6ipa)2, and Zn(6bpa)2 (IC50 = 0.64, 0.60, 0.77, 0.85, and 0.50 mM, respectvely) were found to be higher than that of bis(picolinato)/zinc(II) complex (Zn(pic)2) (IC50 = 1.00 mM) in terms of IC50 value, the 50% inhibition concentrations for the FFA release from rat adipocytes.
Journal
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- Biomedical Research on Trace Elements
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Biomedical Research on Trace Elements 15 (1), 85-87, 2004
Japan Society for Biomedical Research on Trace Elements
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Details 詳細情報について
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- CRID
- 1390001204366347648
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- NII Article ID
- 130004456749
- 10028287164
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- NII Book ID
- AN10423256
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- COI
- 1:CAS:528:DC%2BD2cXjsleksLs%3D
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- ISSN
- 18801404
- 0916717X
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- NDL BIB ID
- 6914114
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed
