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- Igarashi Osamu
- Department of Neurology, Toho University Omori Hospital
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- Ikeda Ken
- Department of Neurology, Toho University Omori Hospital
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- Iwasaki Yasuo
- Department of Neurology, Toho University Omori Hospital
書誌事項
- タイトル別名
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- relation between trace elements and amyotrophic lateral sclerosis
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抄録
Amyotrophic lateral sclerosis (ALS) is characteristic of selective degeneration of the upper and lower motor neurons. The correct pathogenesis of this fatal disease is unknown. Several possible mechanism of motor neuron degeneration is postulated in ALS. In particular, gene mutation of Cu/Zn superoxide dismutase (SOD) is discovered in a part of familial ALS patients. The evidence suggests a major possibility that trace elements, such as Cu and Zn, may have toxic effects on motor neurons. We review shortly the relationship between several trace elements and ALS. We hope that neurotoxic studies of metals and other trace elements could contribute to further therapeutic potential and strategy in ALS.
収録刊行物
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- Biomedical Research on Trace Elements
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Biomedical Research on Trace Elements 16 (1), 9-11, 2005
日本微量元素学会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390001204367240704
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- NII論文ID
- 130004456793
- 10019039702
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- NII書誌ID
- AN10423256
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- ISSN
- 18801404
- 0916717X
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- NDL書誌ID
- 7781992
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可