GPI-Anchor: Update for Biosynthesis and Remodeling

DOI Web Site 119 References Open Access
  • Maeda Yusuke
    WPI Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan PREST, Japan Society of Technology, Saitama, Japan
  • Fujita Morihisa
    Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan CREST, Japan Society of Technology, Saitama, Japan
  • Kinoshita Taroh
    WPI Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan CREST, Japan Society of Technology, Saitama, Japan

Bibliographic Information

Other Title
  • ＧＰＩ　アンカーの生合成・構造改変に関するｕｐｄａｔｅ
  • GPIアンカーの生合成・構造改変に関するupdate[含 英語文]
  • GPI アンカー ノ セイゴウセイ コウゾウ カイヘン ニ カンスル update ガン エイゴブン

Search this article

Description

Post-translational modifications to proteins play important roles in biological function, and alteration of these modifications according to cellular conditions is a sophisticated way to regulate protein activity. Glycosylphosphatidylinositol (GPI) is a glycolipid covalently attached to proteins, and it represents a post-translational modification that anchors proteins to the plasma membrane--called a GPI-anchor. The GPI-anchor is conserved among all eukaryotes and more than 150 proteins of various functions are modified with a GPI-anchor. The GPI-anchor is essential for the growth of yeasts and some protozoans, and defects in GPI-anchors are associated with a number of human diseases. This review focuses on the recent progress and topics in mammalian GPI-anchor biosynthesis, structural remodeling and diseases associated with GPI-anchor dysfunction.

Journal

References(119)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top