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- Hirashima Mitsuomi
- Department of Immunology and Immunopathology, Faculty of Medicine, Kagawa University Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University GalPharma Co., Ltd.
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- Niki Toshiro
- Department of Immunology and Immunopathology, Faculty of Medicine, Kagawa University GalPharma Co., Ltd.
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- Masaki Tsutomu
- Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University
書誌事項
- タイトル別名
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- Galectin-9 Changes Its Function to Maintain Homeostasis
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説明
<p>Galectin-9 (Gal-9)/Ecalectin was first identified as a T cell-derived eosinophil chemoattractant. We found that Gal-9 plays a role in not only the accumulation but also the activation of eosinophils in experimental allergic models and human allergic patients; Gal-9 was shown to induce eosinophil chemotaxis in vitro and in vivo and activated eosinophils in various aspects. Recent studies, however, showed that Gal-9 has other functions in the differentiation, maturation, aggregation, adhesion, and death of various cells. Presently, we and other groups are in the process of investigating the function of Gal-9 in a variety of physiological and pathological conditions. In this article, we will show the in vivo therapeutic effects of Gal-9 in various disease models (both hyper-immune and immune-compromised conditions), suggesting that Gal-9’s immune function changes according to the context. Indeed, the accumulated evidence suggests that Gal-9 orchestrates a variety of biological phenomena to maintain homeostasis.</p>
収録刊行物
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- Ｔｒｅｎｄｓ ｉｎ Ｇｌｙｃｏｓｃｉｅｎｃｅ ａｎｄ Ｇｌｙｃｏｔｅｃｈｎｏｌｏｇｙ
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Ｔｒｅｎｄｓ ｉｎ Ｇｌｙｃｏｓｃｉｅｎｃｅ ａｎｄ Ｇｌｙｃｏｔｅｃｈｎｏｌｏｇｙ 30 (172), SE109-SE118, 2018
FCCA(Forum: Carbohydrates Coming of Age)
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詳細情報 詳細情報について
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- CRID
- 1390001204369021952
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- NII論文ID
- 130006319060
- 130006319061
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- ISSN
- 18832113
- 09157352
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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