リポ多糖中のＯ‐抗原多糖の１つのおもしろい性質　　Ｌｅｗｉｓ血液型抗原を介したＨｅｌｉｃｏｂａｃｔｅｒ　ｐｙｌｏｒｉリポ多糖と宿主とのクロストーク

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  • Amano Ken-ichi
    Central Research Laboratory, Akita University School of Medicine

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タイトル別名
  • An Interesting Property of O-Antigen Polysaccharide in Lipopolysaccharide: Cross-Talk between Lipopolysaccharides of Helicobacter pylori and Host Cells through Lewis Blood Group Antigens.
  • リポ タトウ チュウ ノ O コウゲン タトウ ノ 1ツ ノ オモシロイ セイシツ Lewis ケツエキガタ コウゲン オ カイシタ Helicobacter pylori リポ タトウ ト シュクシュ ト ノ クロストーク ガン エイブン
  • Cross-Talk between Lipopolysaccharides of <i>Helicobacter pylori</i> and Host Cells through Lewis Blood Group Antigens
  • Lewis 血液型抗原を介した <i>Helicobacter pylori</i> リポ多糖と宿主とのクロストーク

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説明

In humans, various peptic diseases and ailments are attributed to infection by the Gram-negative bacterium, Helicobacter pylori. Among the various pathogenic factors of H. pylori, the lipopolysaccharides (LPS) display two different characteristics to LPS of other Gram-negative bacteria. These include low biological activity and the presence of structures similar to human blood Lewis antigens. The former is derived from H. pylori lipid A structure that contains long fatty acids (βOHC18, βOHC16 and C16) and is deficient in the phosphate group at the non-reducing end of glucosamine disaccharide, compared to the lipid A structure of Escherichia coli. Epitopes similar to the Lewis antigen structure are present in the non-reducing end unit of the O-polysaccharide moiety, which may lead to the adhesion and colonization of this bacterium with human gastric epithelial cells. Recently, epitopes distinct from Lewis related antigens were identified in the O-polysaccharide moiety. These novel epitopes appear to be associated with peptic disease.

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