Dynamics and Spatial Organization of Surface Gangliosides.

DOI Web Site 3 Citations 45 References
  • Brocca Paola
    Study Center for the Functional Biochemistry of Brain Lipids, Department of Medical Chemistry and Biochemistry, The Medical School, University of Milan
  • Sonnino Sandro
    Study Center for the Functional Biochemistry of Brain Lipids, Department of Medical Chemistry and Biochemistry, The Medical School, University of Milan Dipartimento di Chimica e Biochimica Medica
  • 小倉 美佐
    東京医科歯科大学・医学部・分子医化学

Bibliographic Information

Other Title
  • 表面ガングリオシドの動力学および空間的配置
  • ヒョウメン ガングリオシド ノ ドウリキガク オヨビ クウカンテキ ハイチ ガ

Search this article

Abstract

Model surfaces in a water environment suitable for the study of membrane ganglioside properties have been developed. They, together with ganglioside micelles of large molecular mass, consist of ganglioside-phosphatidylcholine mixed micelles of small molecular mass and ceramide-modified ganglioside micelles of intermediate molecular mass. The experimental information on the conformational and geometrical properties of ganglio-series gangliosides inserted into these model surfaces is discussed, compared and integrated with that obtained using multilamellar aggregate models.<br>The results show that the conformational properties of the chain are determined by interresidual interactions between the sialic acid and N-acetylgalactosamine units, regardless of the total oligosaccharide structure, the structure of the ganglioside ceramide, possible phospholipid head group or Ca++ interactions, a highly enriched ganglioside environment, the presence of cholesterol in the membrane or temperature variation. Furthermore, the oligosaccharide chain seems to be well extended beyond the bilayer surface with a well defined average conformation and motional order, common to all the investigated gangliosides.

Journal

Citations (3)*help

See more

References(45)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top