Photoaffinity Labeling Approaches toward Identification of Carbohydrate–Lectin Interactions

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  • Sakurai Kaori
    Department of Bioengineering and Life Science, Tokyo University of Agriculture and Technology

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  • 糖鎖–レクチン相互作用の探索に向けたフォトアフィニティーラベリング法の開発
  • Photoaffinity Labeling Approaches toward Identification of Carbohydrate^|^#x2013;Lectin Interactions

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Abstract

Cell surface carbohydrates play important roles in many biological and pathological processes. One of their modes of activity is through binding interactions with lectins. However, many of carbohydrate–lectin interactions are thought to remain unknown due to their low affinity, overlapping specificity and the lack of general tools to detect and isolate specific lectins. Photoaffinity labeling has emerged as a promising approach to investigate often elusive carbohydrate–protein interactions. This minireview aims to illustrate challenges associated in identifying carbohydrate–lectin interactions and to briefly present past developments in the design of carbohydrate photoaffinity probes.

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