The Role of Galectins in Mouse Development.
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- Colnot Céline
- Unité INSERM 257, ICGM, 24 rue du Faubourg Saint-Jacques
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- Ripoche Marie-Anne
- Unité INSERM 257, ICGM, 24 rue du Faubourg Saint-Jacques
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- Fowlis Deborah
- Unité INSERM 257, ICGM, 24 rue du Faubourg Saint-Jacques
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- Cannon Virginetta
- Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California
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- Scaerou Frédéric
- Unité INSERM 257, ICGM, 24 rue du Faubourg Saint-Jacques
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- Cooper Douglas. N. W.
- Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California
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- Poirier Françoise
- Unité INSERM 257, ICGM, 24 rue du Faubourg Saint-Jacques
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- 荒田 洋一郎
- 帝京大学薬学部生物化学教室
Bibliographic Information
- Other Title
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- マウスの発生におけるガレクチンの役割
- マウス ノ ハッセイ ニ オケル ガレクチン ノ ヤクワリ
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Abstract
Galectins are members of a family of carbohydrate-recognizing molecules specific for β-galactosides, distinguishable from all other animal lectins by their low molecular weight, ranging from 14kDal to 36kDal, and their variable subcellular location. Ten members of this gene family have now been identified.<br>Studies of the spatio-temporal distribution of various galectins during embryogenesis have shown that these molecules present very dynamic patterns of expression, suggesting roles in several developmental processes.<br>In an attempt to elucidate the potential functions of these proteins during embryogenesis, we have generated mutants with targeted deletions of galectin-1 and galectin-3 genes. Animals homozygous for either of these mutations are viable and fertile. Despite the coexpression of galectins-1 and -3 on the surface of the embryo at the time of uterine implantation, double homozygote embryos also implant successfully and the combined loss of galectins-1 and 3 does not lead to any overt phenotype. Detailed analysis of these animals is in progress.
Journal
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- Trends in Glycoscience and Glycotechnology
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Trends in Glycoscience and Glycotechnology 9 (45), 31-40, 1997
FCCA(Forum: Carbohydrates Coming of Age)
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Keywords
Details 詳細情報について
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- CRID
- 1390001204369852288
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- NII Article ID
- 130003699274
- 10012212929
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- NII Book ID
- AA10995236
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- ISSN
- 18832113
- 09157352
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- NDL BIB ID
- 4173242
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed