コンドロイチン硫酸／デルマタン硫酸の機能発現における特異的硫酸化の生物学的重要性

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  • Mikami Tadahisa
    Department of Biochemistry, Kobe Pharmaceutical University
  • Sugahara Kazuyuki
    Present address: Graduate School of Life Science, Faculty of Advanced Life Science, Hokkaido University, Frontier Research Center for Post-Genomic Science and Technology

書誌事項

タイトル別名
  • The Biological Importance of Specific Sulfation of Chondroitin Sulfate/Determatan Sulfate in Their Functional Expression
  • コンドロイチン リュウサン デルマタン リュウサン ノ キノウ ハツゲン ニ オケル トクイテキ リュウサンカ ノ セイブツガクテキ ジュウヨウセイ ガン エイブン

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説明

Chondroitin sulfate (CS) and dermatan sulfate (DS) are widely distributed as sulfated glycosaminoglycan side chains of proteoglycans in extracellular matrices and at cell surfaces. Increasing evidence suggests the importance of CS/DS chains in several biological functions. For example, in the development and regeneration of the central nervous system, they have apparently contradictory roles as neuritogenic molecules and as major inhibitors of axonal pathfinding and regeneration. These functions are closely associated with the characteristic sulfated structures embedded in the CS/DS chains, and are exerted through distinct molecular mechanisms, at least in part, by specific interactions between CS/DS chains and heparin-binding growth factors.

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