Toxic shock syndrome toxin 1(TSST-1) and endotoxin levels in patients with severe sepsis.
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- Yokota Tohru
- First Department of Surgery, Shiga University of Medical Science
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- Kobayashi Tomoe
- First Department of Surgery, Shiga University of Medical Science
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- Hanasawa Kazuyoshi
- First Department of Surgery, Shiga University of Medical Science
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- Endo Yoshihiro
- First Department of Surgery, Shiga University of Medical Science
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- Tani Tohru
- First Department of Surgery, Shiga University of Medical Science
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- Kodama Masashi
- First Department of Surgery, Shiga University of Medical Science
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- Miwa Keishi
- Medical Device & Diagnostics Research Laboratories, Toray Industries Inc.
Bibliographic Information
- Other Title
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- 重症感染症例における血中toxic shock syndrome toxin‐1(TSST‐1)およびエンドトキシン濃度に関する検討
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Abstract
The plasma TSST-1 and endotoxin levels were measured in 54 samples from 41 septic patients. The plasma TSST-1 levels were measured by ELISA. “TSST-1 positive” was defined as more than 100pg/ml in plasma. The plasma endotoxin levels were measured by the chromogenic Limulus test. “Endotoxin positive” was defined as more than 9.8pg/ml in plasma. All patients received direct hemoperfusion with polymixin B-immobilized fiber (PMX) that removes endotoxin from the blood. Mortality was evaluated at 2 weeks after direct hemoperfusion. Forty-six samples (85.2%) were endotoxin positive. Thirty-five samples (64.8%) were TSST-1 positive. Thirty-two samples were both endotoxin and TSST-1 positive. Five samples were both TSST-1 and endotoxin negative. TSST-1 levels in the endotoxin positive group were significantly higher than those in the endotoxin negative group (250.5±406.3 vs 67.7±72.4pg/ml, mean+SD, p<0.05). There is no difference in endotoxin and TSST-1 levels between survivors and non-survivors. The septic severity score and number of failing organs in the non-survivor group are significantly higher than those in the survivor group. TSST-1 prolonged endotoxin clearance from the blood. In severe sepsis, it is believed that polymicrobial infections are frequently complications and caused the poor prognosis.
Journal
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- Nihon Kyukyu Igakukai Zasshi
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Nihon Kyukyu Igakukai Zasshi 9 (2), 53-59, 1998
Japanese Association for Acute Medicine
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Keywords
Details 詳細情報について
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- CRID
- 1390001204370673792
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- NII Article ID
- 130003437723
- 10006372411
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- NII Book ID
- AN10284604
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- ISSN
- 18833772
- 0915924X
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed