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- Fujita Morihisa
- Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan
書誌事項
- タイトル別名
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- Potential Roles of GPI-Anchor Remodeling in Protein Trafficking and Raft Association in Mammalian Cells
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Post-translational modification of proteins with glycosylphosphatidylinositol (GPI) is mediated by a mechanism that is conserved in all eukaryotes. GPI-anchored proteins are characterized by their association with specialized membrane domains called “lipid rafts,” and the GPI-anchors are thought to regulate their intracellular trafficking pathways. These characteristics are regulated by the structural properties of GPI-anchors, remodeling enzymes and recognition molecules. The biogenesis of GPI-anchored proteins occurs in the ER, following which they are transported to the plasma membrane via the Golgi apparatus. During transport, the structures of the GPI-anchors are remodeled. In this minireview, the structural remodeling of mammalian GPI-anchors and regulation of the transport and localization of GPI-anchored proteins are described.
収録刊行物
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- Ｔｒｅｎｄｓ ｉｎ Ｇｌｙｃｏｓｃｉｅｎｃｅ ａｎｄ Ｇｌｙｃｏｔｅｃｈｎｏｌｏｇｙ
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Ｔｒｅｎｄｓ ｉｎ Ｇｌｙｃｏｓｃｉｅｎｃｅ ａｎｄ Ｇｌｙｃｏｔｅｃｈｎｏｌｏｇｙ 24 (140), 244-257, 2012
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詳細情報 詳細情報について
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- CRID
- 1390001204370737408
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- NII論文ID
- 10031146677
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- NII書誌ID
- AA10995236
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- ISSN
- 18832113
- 09157352
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- NDL書誌ID
- 024179996
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可