The study of glycopeptide syntheses: exploring concise O-linked sialylglycopeptide synthesis and glycopeptide coupling reaction
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- Okamoto Ryo
- International Graduate School of Arts and Sciences, Yokohama City University
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- Kajihara Yasuhiro
- International Graduate School of Arts and Sciences, Yokohama City University
Bibliographic Information
- Other Title
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- 糖ペプチドの合成研究:簡便なO型シアリル糖ペプチドの合成と糖ペプチド連結法の探索
- 糖ペプチドの合成研究--簡便なO型シアリル糖ペプチドの合成と糖ペプチド連結法の探索[含 英語文]
- トウ ペプチド ノ ゴウセイ ケンキュウ カンベンナ Oガタ シアリル トウ ペプチド ノ ゴウセイ ト トウ ペプチド レンケツホウ ノ タンサク ガン エイゴブン
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Abstract
For the preparation of both N-linked and O-linked sialylglycopeptides and their glycoprotein form, the critical points in these syntheses are the preparation of an appropriate amount of sialyloligosaccharyl-amino acid and isolation of the sialylglycopeptides. In particular, it have been difficult to isolate O-linked sialylglycopeptides in which the sialyl linkage is labile to acid treatment and the N-acetyl-galactosaminyl linkage is labile to base-treatment. For the preparation of target glycoproteins by the use of such sialylglycopeptide thus obtained, an efficient coupling method should be essential. In this review, we introduce our new sialyl donors for the synthesis of sialyl-TN epitope and O-linked sialyl-TN-glycopeptides, and a new concept for a glycopeptide coupling reaction in the synthesis of glycoproteins.<br>
Journal
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- Trends in Glycoscience and Glycotechnology
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Trends in Glycoscience and Glycotechnology 20 (114), 203-217, 2008
FCCA(Forum: Carbohydrates Coming of Age)
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Details 詳細情報について
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- CRID
- 1390001204370844288
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- NII Article ID
- 10024593569
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- NII Book ID
- AA10995236
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- ISSN
- 18832113
- 09157352
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- NDL BIB ID
- 9722336
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed