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- Tvaroška Igor
- Institute of Chemistry, Slovak Academy of Sciences
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- 酒井 啓一郎
- 生化学工業株式会社中央研究所
書誌事項
- タイトル別名
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- Structural Insights into the Catalytic Mechanism and Transition State of Glycosyltransferases Using ab initio Molecular Modeling
- ab initio ブンシ モデリング オ モチイタ トウ テンイ コウソ ノ ショクバイ キコウ ト センイ ジョウタイ ノ コウゾウテキ ドウサツ ガン エイゴ ゲンブン
この論文をさがす
抄録
Glycosyltransferases are found in most living organisms, and they are involved in the biosynthesis of carbohydrates catalyzing the transfer of a saccharide residue to a specific acceptor. Despite the important roles that carbohydrates play in numerous biological events, the molecular details of the catalytic mechanism of these enzymes are generally not well understood, and consequently the progress in development of therapeutics based on their inhibitions has been relatively slow. High-level quantum mechanical calculations can be used to gain some insight into characteristics of the enzymatic reactions, and they lead to a deeper understanding of glycosyltransferases catalysis. In addition, the computed transition state structures provide a rational basis for design of transition state analog inhibitors.
収録刊行物
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- Trends in Glycoscience and Glycotechnology
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Trends in Glycoscience and Glycotechnology 17 (96), 177-190, 2005
FCCA(Forum: Carbohydrates Coming of Age)
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詳細情報 詳細情報について
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- CRID
- 1390001204371322368
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- NII論文ID
- 130003698939
- 10019359956
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- NII書誌ID
- AA10995236
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- ISSN
- 18832113
- 09157352
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- NDL書誌ID
- 7688620
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
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- 使用不可