Deacetylation of Grayailotoxin Acetates with Ammonia Water

DOI Web Site
  • TERAI Tadamasa
    Department of Applied Chemistry, Faculty of Engeneering, Osaka Institute of Technology Omiya,

Bibliographic Information

Other Title
  • Grayanotoxin Acetate のアンモニア水による脱アセチル反応
  • Investigations on grayanotoxins. III. Deacetylation of grayanotoxin acetates with ammonia water.

Description

Grayanotoxins(G) are toxic diterpenoids found in Leucothoe grayana MAX. (Ericaceae), and G-I--G-XX have been hitherto isolated. In this paper, the rates of deacetylation of 14-mon oacetate[1] 6, 14-diacetate [3] and 6-monoacetate[4] with aqueous ammonia were studied by the TLC method. The observed rate constant(kobs) and halftime(r) of deacety lation in each reaction conditions are shown in Table 1. The deacetylation rate of C - 6-OAc was slower than that of C-14-OAc. The first step of reactions [3]-[4]--[2] obeyed g o od first order kinetics, and the[4]-[2] part was inhibited by ammonium acetate for m ed under these conditions.

Journal

  • NIPPON KAGAKU KAISHI

    NIPPON KAGAKU KAISHI 1985 (4), 747-752, 1985-04-10

    The Chemical Society of Japan

Keywords

Details 詳細情報について

Report a problem

Back to top