Brain Glucose Metabolism in Patients with Acute Carbon Monoxide Poisoning : An Evaluation using ^<18>F-fluorodeoxyglucose (FDG) Positron Emission Tomography (PET)
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- Kawai Nobuyuki
- Department of Neurological Surgery, Kagawa University Faculty of Medicine
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- Hatakeyama Tetsuhiro
- Department of Neurological Surgery, Kagawa University Faculty of Medicine
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- Kuroda Yasuhiro
- Department of Radiology, Kagawa University Faculty of Medicine
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- Yamashita Susumu
- Department of Radiology, Kagawa University Faculty of Medicine
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- Nishiyama Yoshihiro
- Critical Care Center, Kagawa University Hospital Faculty of Medicine
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- Tamiya Takashi
- Department of Neurological Surgery, Kagawa University Faculty of Medicine
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- Nagao Seigo
- Department of Neurological Surgery, Kagawa University Faculty of Medicine
Bibliographic Information
- Other Title
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- 一酸化炭素中毒患者における脳ブドウ糖代謝 : ^<18>F-fluorodeoxyglucose(FDG)positron emission tomography(PET)を用いた検討
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Description
We examined glucose metabolism using positron emission tomography (PET) in 2 patients with acute carbon monoxide (CO) poisoning. In the first case, a 15-year-old woman suffering from acute and moderate CO poisoning was treated with hyperbaric oxygen (HBO) therapy and underwent PET scan examinations using <15>O-labeled gas and <18>F-fluorodeoxyglucose (FDG). Although hypoperfusion was not apparent, reduced glucose metabolism in the bilateral globus pallidus and thalamus and frontal cortex was observed on the FDG-PET scan that was examined immediately after the first HBO therapy. MRI revealed high-signal intensity in the left globus pallidus on the diffusion-weighted image, the patient, however, did not develop any delayed neuropsychiatric complications. In the second case, a 19-year-old man suffering from acute and moderate CO poisoning underwent FDG-PET examination 8 days after the CO poisoning. Reduced glucose metabolism in the bilateral globus pallidus and thalamus and frontal cortex was observed on the FDG-PET image. MRI revealed high-signal intensities in the bilateral globus pallidus and frontal and parietal white matter on the diffusion-weighted image and the patient resulted in chronic unresponsiveness. Reduced glucose metabolism in the bilateral globus pallidus and thalamus and frontal cortex might be a common finding in patients with acute CO poisoning. Evaluation in two patients does not validate the usefulness of FDG-PET examination in the determination of neuropsychiatric prognosis in patients with CO poisoning, however, PET has possible utility in gaining further understanding of the pathophysiological characteristics of human CO poisoning.
Journal
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- Japanese Journal of Neurosurgery
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Japanese Journal of Neurosurgery 15 (6), 473-479, 2006
The Japanese Congress of Neurological Surgeons
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Details 詳細情報について
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- CRID
- 1390001204407443712
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- NII Article ID
- 110004732005
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- NII Book ID
- AN10380506
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- ISSN
- 21873100
- 0917950X
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
- OpenAIRE
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- Abstract License Flag
- Disallowed
