A Case Report of Neurofibromatosis Type 2 associated with Multiple Intracranial and Spinal Tumors : Management of Intramedullary Spinal Tumors in Neurofibromatosis Type 2

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  • 頭蓋内, 脊髄に多発性腫瘍を合併したneurofibromatosis type 2の1例 : 脊髄髄内腫瘍の治療について

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It is well known that neurofibromatosis type 2(NF 2)has bilateral acoustic schwannomas and lack genes on chromosome 22. We presented 26-year-old man diagnosed as NF 2 by radiological and chromosomal examination. We found multiple tumors both in cranial and spinal region, and resected the symptomatic lumbar schwannomas and the thoracic ependymoma. Recent reports also showed that NF 2 has characteristically associates multiple tumors both in cranial and spinal portion. Reviewing of literatures, 40 cases have been reported about intramedullary spinal cord tumor associated with NF 2. Surgical results of spinal scwannoma and ependymoma are almost good. Because the tumors with clear margin are either ependymoma or schwannoma, most of them could be totaly removed. We conclude that the symptomatic intramedullary tumors with clear margin have also good operative indication even if they are associated with NF 2.

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