Clinical Evaluation of the Use of a Local Drug Delivery System in Periodontal Therapy.

  • KIMURA Kazumori
    Department of Clinical Periodontology Ohu University School of Dentistry
  • MINABE Masato
    Department of Clinical Periodontology Ohu University School of Dentistry
  • IIDA Masato
    Department of Clinical Periodontology Ohu University School of Dentistry

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  • 歯周治療におけるLDDS(ペリオクリン)の位置づけに関する臨床的検討

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The present clinical study was performed to ascertain the optimum time for antibiotic administration by a local drug delivery system in combination with root planing (RP).<BR>Minocycline slow-release ointment was applied locally either before or after, or both before and after RP (once/week for 4 weeks). The plaque index, gingival index, bleeding on probing (BOP), probing depth and probing attachment level were determined during a clinical examination conducted on the first visit, and immediately before and 2 months after RP.<BR>The local application of minocycline slow-release ointment before RP was found to decrease the rate of BOP and increase clinical attachment levels. It was also found that the rate of probing attachment gain increased after RP in sites without BOP before RP.

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