Study of interleukin 1 in periodontitis.

DOI PubMed 5 Citations
  • IIYAMA Masao
    Department of Endodontics and Periodontics, Tohoku University School of Dentistry

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  • 辺縁性歯周炎に対するインターロイキン１の関与

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The interleukin 1 (IL-1) -activity, and partially the interleukin 2 and 3 (IL-2, 3) -activity of gingival crevicular fluids (GF) were analized to examine the role of immunological kinetics in marginal periodontitis. And peritoneally elicited macrophages of mice (PEC M.O) were stimulated with several bacteria to estimate the ability of bacteria to induce the production of IL-1 by macrophages. Extracellular and intracellular IL-1 activity were separately measured.<BR>The results were as follows:<BR>All of GF examined had IL-1 like (GFIL-1) activity. A significant linear relationship was obtained between the pocket depth and GFIL-1 activity, when defined the samples from the pockets under 8mm. Analysis of two samples which had high GFIL-1 activity, revealed that the molecular weight of this activity was 13.5-17 KD.<BR>None of GF samples examined had IL-2 and IL-3 activity.<BR>The ability to induce the production of IL-1 by PEC M.O was high in such bacteria that had high endotoxic activity. This relationship was also found in the case of bacteria which were thought to be pathogenic in periodontitis.<BR>Findings suggest that the analysis of endotoxic activity of bacteria which exist predominantly in inflamed periodontal tissue, and of actual status of IL-1 producing cells, might give support to the understanding of marginal periodontitis.

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