Clinical and microbiological effect of newly developed OTC periodontal ointment-containing applicator with brush on the SPT phase

Inubushi Junya, Hatanaka Kazu, Yasuda Takako, Naruishi Koji, Ootsuki Hidehiko, Takashiba Shogo

doi:10.2329/perio.52.225

It is important for maintaining improved periodontal tissue health during supportive periodontal therapy (SPT) to restrain infection caused by periodontopathic bacteria by the patients' own self control in addition to periodic professional intervention. We developed an over-the-counter (OTC) medication, named MC1, consisting of a one-tuft brush containing the compound cetylpyridinium chloride (CPC) as a bactericidal agent, dipotassium glycyrrhizate (GK2) as an anti-inflammatory drug, and allantoin (ALT) as a promoter of cell proliferation and wound healing, for delivery to hardly-brushed regions. In this study, we evaluated the effectiveness of MC1 clinically and microbiologically in maintaining improved periodontal tissue status during SPT.<BR>This study was designed as a double-blind clinical trial targeting chronic periodontitis patients during the SPT phase. Sixty-one subjects (test group: 27 subjects, placebo group: 28 subjects, dropout: 6 subjects) participated in this study, and applied MC1 to 2 molar periodontal pockets ≥ 4mm twice a day for 12 weeks. The clinical indicators used were the probing pocket depth (PPD), bleeding on probing (BOP), plaque control record (PCR), gingival index (GI), and weight of the gingival crevicular fluid (GCF). The microbiological indicators were the number of total bacteria, Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola. These were evaluated at the baseline, and at the 6- and 12-week time-points.<BR>All of the clinical indicators other than PCR were significantly improved in both groups in a time-dependent manner, and earlier improvement tended to be noted in the test group with GI and GCF volume than in the placebo group. On the other hand, the numbers of all of the examined bacteria at sites with a PPD ≥5mm were significantly improved in the test group as compared with those in the placebo group.<BR>It is suggested that MC1 is effective in maintaining the state of the periodontal tissue clinically and microbiologically in chronic periodontitis patients during the SPT phase.<BR>Nihon Shishubyo Gakkai Kaishi(J Jpn Soc Periodontol)52(3) : 225-238, 2010.

Clinical and microbiological effect of newly developed OTC periodontal ointment-containing applicator with brush on the SPT phase

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