歯槽骨吸収における免疫系の関与についての病理組織学的研究　ＳＣＩＤマウス歯肉への内毒素投与による変化

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  • A Histopathological Study on Participitation of the Immune System in Alveolar Bone Resorption. Influence of Endotoxin Derived from Escherichia coli on Tissue Changes in SCID Mouse Gingiva.
  • Influence of Endotoxin Derived from Escherichia coli on Tissue Changes in SCID Mouse Gingiva
  • CIDマウス歯肉への内毒素投与による変化

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The aim of this study was to histopathologically clarify the role of B lymphocytes on the initiation time and the degree of destruction of periodontal tissue when endotoxin derived from Escherichia coli was injected into the gingiva of severe combined immunodeficient (SCID) mice. In comparison with our previous report on normal and nude mice using the same methods, the inflammatory changes in the gingiva of SCID mice were milder than in normal mice, and the appearance of osteoclasts in alveolar bone was delayed. These findings were almost the same as in nude mice, except for the proportion of inflammatory cells. These findings suggested that the milder inflammatory changes were due to an absence of functional T and B lymphocytes. On the other hand, the onset of alveolar bone resorption, which was also delayed in nude mice, appears to be more affected by T lymphocytes than B lymphocytes.

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