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Clinical Effects of the Leftose 30mg Tablet for Treatment of the Periodontal Diseases
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- EBISU Shigeyuki
- Department of Periodontology and Endodontology, Osaka University Dental School
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- OKADA Hiroshi
- Department of Periodontology and Endodontology, Osaka University Dental School
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- IMAI Hisao
- Department of Peridontology, Osaka Dental University
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- YAMAOKA Akira
- Department of Peridontology, Osaka Dental University
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- MIYASHITA Hajime
- Department of Periodontics, Showa University Dental School
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- HASEGAWA Koji
- Department of Periodontics, Showa University Dental School
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- IZUMIZAWA Katsunori
- Department of Peiodontology, Shool of Dentistry Tokyo Medical and Dental University
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- ODA Shigeru
- Department of Peiodontology, Shool of Dentistry Tokyo Medical and Dental University
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- KITAMURA Shigeru
- Department of Peiodontology, Shool of Dentistry Tokyo Medical and Dental University
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- KINOSHITA Shiro
- Department of Peiodontology, Shool of Dentistry Tokyo Medical and Dental University
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- SANGU Yoshikuni
- Department of Oral Surgery, Tokyo Women's Medical College
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- KAWANISHI Isshu
- Department of Oral Surgery, Tokyo Women's Medical College
Bibliographic Information
- Other Title
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- 歯周疾患に対するレフトーゼ３０ｍｇ錠の臨床効果
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Description
The purpose of this investigation was to determine the efficacy of Leftose 30mg tablet (lysozyme chloride preparation) in the management of periodontal disease. 145 adults with gingivitis and/or periodontitis were volunteered in this study.<br>Leftose was administered systemically to 124 patients for 3 to 42 days (Leftose group), the remaining 21 patients without Leftose were compared as the control (non-Leftose group).<br>The following clinical measurements were carried out by scoring systems at initial examination and 3 or 7 days after treatment; (a) bleeding, (b) purulent exudation, (e) gingival inflammation, (d) swelling, (e) gingival color, (f) tooth mobility, (g) local pain, (h) halitosis, (i) calculus, (j) plaque and (k) periodontal pocket depth.<br>No statistically significant differences were found between Leftose group and non-Leftose group at the 0.05 level regarding changes in the clinical measurements. In Leftose group, the effectiveness was more pronounced in the cases of 7-day-administration than those of 3-day-administration. This sug gests that higher dose or longer-term administration would be needed for the treatment of Leftose.<br>Local theray such as brushing instruction and/or scaling was significantly effective only in the Leftose group in this limitted condition of 7 days observation (p<0.01). It is considered from this result that Leftose potentiated the effect of the local therapy, but further studies will be needed.
Journal
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- Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology)
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Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) 25 (1), 242-253, 1983
JAPANESE SOCIETY OF PERIODONTOLOGY