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- Furukawa Satoshi
- Biological Research Laboratories, Nissan Chemical Industries, Ltd.
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- Hayashi Seigo
- Biological Research Laboratories, Nissan Chemical Industries, Ltd.
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- Usuda Koji
- Biological Research Laboratories, Nissan Chemical Industries, Ltd.
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- Abe Masayoshi
- Biological Research Laboratories, Nissan Chemical Industries, Ltd.
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- Hagio Soichiro
- Biological Research Laboratories, Nissan Chemical Industries, Ltd.
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- Ogawa Izumi
- Biological Research Laboratories, Nissan Chemical Industries, Ltd.
この論文をさがす
抄録
The placenta grows rapidly for a short period with high blood flow during pregnancy and has multifaceted functions, such as its barrier function, nutritional transport, drug metabolizing activity and endocrine action. Consequently, the placenta is a highly susceptible target organ for drug- or chemical-induced adverse effects, and many placenta-toxic agents have been reported. However, histopathological examination of the placenta is not generally performed, and the placental toxicity index is only the placental weight change in rat reproductive toxicity studies. The placental cells originate from the trophectoderm of the embryo and the endometrium of the dam, proliferate and differentiate into a variety of tissues with interaction each other according to the development sequence, resulting in formation of a placenta. Therefore, drug- or chemical-induced placental lesions show various histopathological features depending on the toxicants and the exposure period, and the pathogenesis of placental toxicity is complicated. Placental weight assessment appears not to be enough to evaluate placental toxicity, and reproductive toxicity studies should pay more attention to histopathological evaluation of placental tissue. The detailed histopathological approaches to investigation of the pathogenesis of placental toxicity are considered to provide an important tool for understanding the mechanism of teratogenicity and developmental toxicity with embryo lethality, and could benefit reproductive toxicity studies.
収録刊行物
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- Journal of Toxicologic Pathology
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Journal of Toxicologic Pathology 24 (2), 95-111, 2011
日本毒性病理学会
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詳細情報 詳細情報について
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- CRID
- 1390001204413779456
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- NII論文ID
- 10030980120
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- NII書誌ID
- AN10232280
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- COI
- 1:STN:280:DC%2BC387ntF2ksQ%3D%3D
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- ISSN
- 1881915X
- 09149198
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- NDL書誌ID
- 11170376
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- PubMed
- 22272049
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可