Two types of deposits, hyaline droplets and eosinophilic bodies, associated with α[2u]-globulin accumulation in the rat kidney

DOI Web Site Web Site 被引用文献3件 参考文献7件
  • Hamamura Masao
    Pathology Department, Kumamoto Laboratory, Nonclinical Research Center, LSI Medience Corporation, 1285 Kurisaki-machi, Uto, Kumamoto 869-0425, Japan
  • Oshikata Takafumi
    Pathology Department, Kumamoto Laboratory, Nonclinical Research Center, LSI Medience Corporation, 1285 Kurisaki-machi, Uto, Kumamoto 869-0425, Japan
  • Katoku Koshirou
    Pathology Department, Kumamoto Laboratory, Nonclinical Research Center, LSI Medience Corporation, 1285 Kurisaki-machi, Uto, Kumamoto 869-0425, Japan
  • Tsuchitani Minoru
    Pathology Department, Kumamoto Laboratory, Nonclinical Research Center, LSI Medience Corporation, 1285 Kurisaki-machi, Uto, Kumamoto 869-0425, Japan
  • Yamaguchi Ryoji
    Pathology Department, Kumamoto Laboratory, Nonclinical Research Center, LSI Medience Corporation, 1285 Kurisaki-machi, Uto, Kumamoto 869-0425, Japan

書誌事項

タイトル別名
  • Two types of deposits, hyaline droplets and eosinophilic bodies, associated with α<sub>2u</sub>-globulin accumulation in the rat kidney

この論文をさがす

抄録

<p> Alpha2u-globulin is an adult male rat-specific protein that accumulates spontaneously or inductively in the renal proximal tubular epithelium and forms microscopically observable deposits, which are generally referred to as “hyaline droplets,” whereas a specific type of deposits is referred to as “eosinophilic bodies” by Japanese toxicologic pathologists. We compared hyaline droplets and eosinophilic bodies using special stains including immunostaining for α2u-globulin and lysosome-associated membrane protein in spontaneously occurring and d-limonene-induced cases. Eosinophilic bodies appeared simultaneously and increased in parallel with the hyaline droplets in the induced case. In both of the spontaneous and induced cases, hyaline droplets and eosinophilic bodies were associated with α2u-globulin and lysosomes, although there were differences in the forms and staining properties that probably reflected the purity or density of α2u-globulin. According to the results, it is not necessary for eosinophilic bodies to be strictly distinguished from hyaline droplets, and it is reasonable to identify eosinophilic bodies as hyaline droplets in α2u-globulin nephropathy in routine toxicity studies, as they have been recognized to be a sequence of changes associated with accumulation of α2u-globulin.</p>

収録刊行物

被引用文献 (3)*注記

もっと見る

参考文献 (7)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ