Spontaneous Nephroblastoma with Lung Metastasis in a Rat
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- Ito Yuko
- Department of Toxicology, Drug Safety Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.
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- Matsushita Kohei
- Department of Toxicology, Drug Safety Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.
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- Tsuchiya Takuma
- Department of Toxicology, Drug Safety Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.
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- Kohara Yukari
- Department of Toxicology, Drug Safety Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.
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- Yoshikawa Tsuyoshi
- Department of Toxicology, Drug Safety Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.
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- Sato Makoto
- Department of Toxicology, Drug Safety Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.
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- Kitaura Keisuke
- Department of Toxicology, Drug Safety Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.
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- Matsumoto Satoshi
- Department of Toxicology, Drug Safety Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.
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Abstract
This report describes a spontaneous nephroblastoma with lung metastasis in a 10-week-old male Crl:CD(SD) rat. Macroscopically, a white mass in the kidney and two white masses in the lung were observed. Histopathologically, the renal mass was located in the cortex of a kidney, and it caused pressure on the surrounding renal parenchyma. Three components could be distinguished in the tumor: blastemal, epithelial (primitive glomerular/tubular structures) and mesenchymal (neoplastic connective tissues) elements. Immunohistochemically, the tumor cells were positive for Wilms tumor 1 protein (WT1) and vimentin. Metastasis was found in the lung. Thus, the case was diagnosed as a nephroblastoma with lung metastasis.
Journal
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- Journal of Toxicologic Pathology
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Journal of Toxicologic Pathology 27 (1), 91-95, 2014
JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY
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Details 詳細情報について
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- CRID
- 1390001204414111616
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- NII Article ID
- 130003391342
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- NII Book ID
- AN10232280
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- COI
- 1:STN:280:DC%2BC2cnpsFagsQ%3D%3D
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- ISSN
- 1881915X
- 09149198
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- NDL BIB ID
- 025510394
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- PubMed
- 24791073
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed