Uterine Carcinosarcoma in a 2-year-old Female Wistar Hannover GALAS Rat

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  • Takami Shigeaki
    Division of Pathology, National Institute of Health Sciences Pathology and Clinical Examination Laboratory, Safety Assessment Unit, Biosafety Research Center, Foods, Drugs and Pesticides
  • Ogawa Kumiko
    Division of Pathology, National Institute of Health Sciences
  • Umemura Takashi
    Division of Pathology, National Institute of Health Sciences
  • Hibi Daisuke
    Division of Pathology, National Institute of Health Sciences
  • Ishii Yuji
    Division of Pathology, National Institute of Health Sciences
  • Okamura Toshiya
    Division of Pathology, National Institute of Health Sciences
  • Tasaki Masako
    Division of Pathology, National Institute of Health Sciences
  • Inoue Tomoki
    Division of Pathology, National Institute of Health Sciences
  • Suzuki Yuta
    Division of Pathology, National Institute of Health Sciences
  • Jin Meilan
    Division of Pathology, National Institute of Health Sciences
  • Cho Young-Man
    Division of Pathology, National Institute of Health Sciences
  • Nishikawa Akiyoshi
    Division of Pathology, National Institute of Health Sciences

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Carcinosarcomas are rare tumors in humans as well as rats and most commonly occur in the uterus. Recently, we observed a case of incidental carcinosarcoma of the uterus in a female Wistar Hannover GALAS [BrlHan:WIST@Jcl (GALAS)] rat at 2 years of age. Histopathologically, the tumor was characterized by an admixture of malignant epithelial and nonepithelial elements. The carcinomatous components represented a type of endometrial carcinoma, consisting of glandular and solid proliferation of large-sized tumor cells. Prominent mitoses and tumor cell invasion were observed. The sarcomatous components were characterized by multifocal proliferation of severe atypical cells with cartilage matrix and were diagnosed as chondrosarcoma. Transitions between carcinomatous and sarcomatous components were observed, and many tumor cells in the solid lesion showed immunohistochemical reactivity with both cytokeratin and vimentin. Based on these findings, this tumor was diagnosed as a uterine carcinosarcoma. This is the first report of uterine carcinosarcoma in Wistar Hannover GALAS [BrlHan:WIST@Jcl (GALAS)] rats.

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