Pulmonary Fibrosis in Response to Environmental Cues and Molecular Targets Involved in Its Pathogenesis

DOI Web Site Web Site 参考文献299件
  • Yoshida Toshinori
    Laboratory of Pathology, Toxicology Division, The Institute of Environmental Toxicology
  • Ohnuma Aya
    Laboratory of Pathology, Toxicology Division, The Institute of Environmental Toxicology
  • Horiuchi Haruka
    Laboratory of Pathology, Toxicology Division, The Institute of Environmental Toxicology
  • Harada Takanori
    The Institute of Environmental Toxicology

この論文をさがす

抄録

Chronic lung injury resulting from a variety of different causes is frequently associated with the development of pulmonary fibrosis in humans. Although the etiology of pulmonary fibrosis is generally unknown, several sources of evidence support the hypothesis that a number of environmental and occupational agents play an etiologic role in the pathogenesis of this disease. The agents discussed in this review include beryllium, nylon flock, textile printing aerosols, polyvinyl chloride and didecyldimethylammonium chloride. The authors also describe a variety of animal models, including genetically modified mice, in order to investigate the molecular mechanism of pulmonary fibrosis, focusing on chemokine receptors, regulatory T cells and transforming growth factor-β and bone morphogenetic protein signaling. Overall, we propose the concept of toxicological pulmonary fibrosis as a lung disease induced in response to environmental cues.

収録刊行物

参考文献 (299)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ