Spontaneous Basal Cell Carcinoma of the Submandibular Gland in a Rat
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- Kobayashi Yoshihiko
- Sugi Institute of Biological Science Co., Ltd.
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- Eda Hiro
- Sugi Institute of Biological Science Co., Ltd.
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- Kajino Emiko
- Sugi Institute of Biological Science Co., Ltd.
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- Tate Yoshiki
- Sugi Institute of Biological Science Co., Ltd.
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- Hiruma Masami
- Sugi Institute of Biological Science Co., Ltd.
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- Akie Yasuki
- Sugi Institute of Biological Science Co., Ltd.
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- Saito Akemi
- Sugi Institute of Biological Science Co., Ltd.
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- Kadota Toshihito
- Sugi Institute of Biological Science Co., Ltd.
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抄録
At necropsy, a white nodule (about 5 × 3 mm in size) was observed in the right submandibular gland of a 10-week-old female GALAS rat. Histopathologically, oval to spindle-shaped and pale basophilic tumor cells proliferated closely, and formed variably sized foci. The nodule partially spread into or invaded the surrounding normal tissue, and necrotic foci were recognized in the tumor. Immunohistochemically, the nuclei of the tumor cells showed a diffusely positive reaction for p63, and the cytoplasm showed a diffusely positive reaction for cytokeratin and negative reaction for αSMA, vimentin, desmin and S-100. Many tumor cells were positive for PCNA. Ultrastructurally, the tumor cells contained many tonofilaments in the cytoplasm and a few desmosomes at the intercellular portion. Based on these findings, the tumor was diagnosed as a basal cell carcinoma originating from the duct in the rat submandibular gland.<br>
収録刊行物
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- Journal of Toxicologic Pathology
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Journal of Toxicologic Pathology 23 (3), 147-149, 2010
日本毒性病理学会
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詳細情報 詳細情報について
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- CRID
- 1390001204415229696
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- NII論文ID
- 130000450741
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- NII書誌ID
- AN10232280
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- ISSN
- 1881915X
- 09149198
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- NDL書誌ID
- 10850686
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可