Effect of a Large Dose of Di (2-ethylhexyl) phthalate (DEHP) on Hepatic Peroxisome in Cynomolgus Monkeys (Macaca Fascicularis)
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- Satake Shigeru
- Shin Nippon Biomedical Laboratories Co., Ltd. Department of Veterinary Pathology, Faculty of Agriculture, Iwate University The United Graduate School of Veterinary Sciences, Gifu University
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- Nakamura Chika
- Shin Nippon Biomedical Laboratories Co., Ltd.
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- Minamide Yoshiyuki
- Shin Nippon Biomedical Laboratories Co., Ltd.
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- Kudo Shinobu
- Shin Nippon Biomedical Laboratories Co., Ltd.
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- Maeda Hiroshi
- Shin Nippon Biomedical Laboratories Co., Ltd.
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- Chihaya Yutaka
- Shin Nippon Biomedical Laboratories Co., Ltd.
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- Kamimura Yasuhiro
- Shin Nippon Biomedical Laboratories Co., Ltd.
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- Miyajima Hiroaki
- Shin Nippon Biomedical Laboratories Co., Ltd.
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- Sasaki Jun
- Department of Veterinary Pathology, Faculty of Agriculture, Iwate University
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- Goryo Masanobu
- Department of Veterinary Pathology, Faculty of Agriculture, Iwate University The United Graduate School of Veterinary Sciences, Gifu University
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- Okada Kosuke
- Department of Veterinary Pathology, Faculty of Agriculture, Iwate University The United Graduate School of Veterinary Sciences, Gifu University
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Description
To elucidate the effect of a large dose of di (2-ethylhexyl) phthalate (DEHP), a plasticizer and peroxisome proliferator-activated receptor-α (PPARα) agonist, on hepatic peroxisomes, we orally administered 1,000 mg/kg/day, once daily, to 3 male and 4 female cynomolgus monkeys for 28 days consecutively. Light-microscopic and electron microscopic examinations of the liver were carried out in conjunction with measurement of the hepatic fatty acid β-oxidation system (FAOS), carnitine acetyltransferase (CAT) and carnitine palmitoyltransferase (CPT) activities, which are peroxisomal and/or mitochondrial enzyme activities. Electron microscopically, enlargement of the mitochondria was observed with lamellar orientation of the cristae along the major axis. Although the number of peroxisomes showed a tendency to increase when compared with those in a biopsied specimen before treatment, no abnormality in morphology was observed. A slight increase in CPT activity was noted at termination. No changes were noted in hepatic FAOS or CAT activity. In conclusion, although repeated oral treatment of cynomolgus monkeys with a large dose of DEHP induced a subtle increase in the numbers of peroxisomes with slight enlargements of the mitochondria, this low-sensitivity response to peroxisome proliferators in cynomolgus monkeys was considered to be closer to the response in humans than that in rodents.<br>
Journal
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- Journal of Toxicologic Pathology
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Journal of Toxicologic Pathology 23 (2), 75-83, 2010
JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY
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Details 詳細情報について
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- CRID
- 1390001204415576320
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- NII Article ID
- 130000307999
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- NII Book ID
- AN10232280
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- ISSN
- 1881915X
- 09149198
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- NDL BIB ID
- 10756674
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed