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- Hasegawa Mina
- Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
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- Ide Mika
- Safety Research Laboratory, Mitsubishi Tanabe Pharma Corporation
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- Kuwamura Mitsuru
- Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
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- Yamate Jyoji
- Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
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- Takenaka Shigeo
- Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
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説明
Detection of the toxicity of a candidate compound at an early stage of drug development is an emerging area of interest. It is difficult to determine all of the effects of metabolism of a compound using traditional approaches such as histopathology and serum biochemistry. The goal of a metabolomics approach is to determine all metabolites in a living system, with the potential to detect and identify biomarkers involved in toxicity onset. Here, we summarize the metabolic fingerprints for detection and identification of metabolic changes and biomarkers related to drug-induced toxicity using Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS). <br>
収録刊行物
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- Journal of Toxicologic Pathology
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Journal of Toxicologic Pathology 23 (2), 67-74, 2010
日本毒性病理学会
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詳細情報 詳細情報について
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- CRID
- 1390001204415593344
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- NII論文ID
- 10030978709
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- NII書誌ID
- AN10232280
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- ISSN
- 1881915X
- 09149198
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- NDL書誌ID
- 10756653
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可