Comparison of Past and Recent Historical Control Data in Relation to Spontaneous Tumors During Carcinogenicity Testing in Fischer 344 Rats

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  • Ando Ryo
    Pathology Division, Gotemba Laboratories, Bozo Research Center Inc.
  • Nakamura Atsushi
    Pathology Division, Gotemba Laboratories, Bozo Research Center Inc.
  • Nagatani Mariko
    Hamamatsu Branch, Pathology Division, Bozo Research Center Inc.
  • Yamakawa Seiki
    Hamamatsu Branch, Pathology Division, Bozo Research Center Inc.
  • Ohira Toko
    Hamamatsu Branch, Pathology Division, Bozo Research Center Inc.
  • Takagi Mizuho
    Pathology Division, Gotemba Laboratories, Bozo Research Center Inc.
  • Matsushima Keita
    Pathology Division, Gotemba Laboratories, Bozo Research Center Inc.
  • Aoki Ami
    Pathology Division, Gotemba Laboratories, Bozo Research Center Inc.
  • Fujita Yumiko
    Pathology Division, Gotemba Laboratories, Bozo Research Center Inc.
  • Tamura Kazutoshi
    Pathology Division, Gotemba Laboratories, Bozo Research Center Inc.

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説明

In the present survey, the historical data for spontaneous tumors observed in our laboratory was compared in relation to the time-related changes between recent (2000-2004) and past (1990-1999) samples from Fischer 344 rats used in carcinogenicity studies. In the recent samples, there were statistically increased incidences of islet cell adenomas in males and uterine adenocarcinomas in females. On the other hand, there were decreased incidences of pheochromocytomas, prostatic adenomas, pituitary anterior adenomas, large granular lymphocytic (LGL) leukemias and Leydig cell tumors in males and pituitary anterior adenomas in females. Furthermore, there were decreases in the body weights of both sexes at 58 weeks of age in the recent samples, and this may have been related to the decreases in the incidences of pheochromocytomas, Leydig cell tumors, prostatic adenomas and LGL leukemias. Moreover, the decreased incidence of pheochromocytoma in males revealed a positive correlation with a decreased percentage of severe chronic progressive nephropathy (CPN). On the other hand, there were no distinct factors responsible for increased incidences of tumors observed in the recent samples, suggesting a possible genetic drift. In conclusion, the incidences of spontaneous tumors obtained in our laboratory have been changed with time. Smaller body weights in both sexes and reduction in the number of male cases with severe CPN might be related to the reduced incidence of certain types of tumors in recent animals. <br>

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