Evaluation of the Subchronic Toxicity of Dietary Administered Equisetum arvense in F344 Rats
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- Tago Yoshiyuki
- Department of Pathology, Osaka City University Medical School
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- Wei Min
- Department of Pathology, Osaka City University Medical School
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- Ishii Naomi
- Department of Pathology, Osaka City University Medical School
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- Kakehashi Anna
- Department of Pathology, Osaka City University Medical School
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- Wanibuchi Hideki
- Department of Pathology, Osaka City University Medical School
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抄録
Equisetum arvense, commonly known as the field horsetail, has potential as a new functional food ingredient. However, little information is available on its side effects, and the general toxicity of Equisetum arvense has yet to be examined in detail. In the present study, we evaluated the influence of administration in diet at doses of 0, 0.3, 1 and 3% for 13 weeks in male and female F344 rats. No toxicity was detected with reference to clinical signs, body weight, urinalysis, hematology and serum biochemistry data and organ weights. Microscopic examination revealed no histopathological lesions associated with treatment. In conclusion, the no-observed-adverse-effect level (NOAEL) for Equisetum arvense was determined to be greater than 3% in both sexes of F344 rat (males and females: >1.79 g/kg BW/day and >1.85 g/kg BW/day, respectively) under the conditions of the present study. <br>
収録刊行物
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- Journal of Toxicologic Pathology
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Journal of Toxicologic Pathology 23 (4), 245-251, 2010
日本毒性病理学会
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詳細情報 詳細情報について
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- CRID
- 1390001204416154240
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- NII論文ID
- 10030979615
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- NII書誌ID
- AN10232280
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- ISSN
- 1881915X
- 09149198
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- NDL書誌ID
- 10966155
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可