Why don't we use in vitro assays for quantitative risk assessment
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- Yoshimura Isao
- Faculty of Engineering, Tokyo University of Science
Bibliographic Information
- Other Title
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- 統計家からの疑問:in vitro試験のデータから定量的結論を導くのは邪道か?
- トウケイカ カラ ノ ギモン in vitro シケン ノ データ カラ テイリョウテキ ケツロン オ ミチビク ノ ワ ジャドウ カ
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Abstract
This paper discusses, from statistical viewpoint, about the methodology to examine whether substances have threshold on tumorgenecity or genotoxicity based on experiment data. When we try to discriminate models with threshold from those without threshold through in vivo experiment, the necessary sample size n will be too huge to be practical. In vitro assays seem to be more promising. Current methodologies utilized in in vitro assays, however, are not suitable for our purpose because they are involved in the determination of the positivity/negativity of test chemicals, while the methodologies we require are those for estimating dose-response relationships. Collaborative studies among toxicologists and statisticians are desirable to establish reasonable methodologies.
Journal
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- Environmental Mutagen Research
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Environmental Mutagen Research 27 (2), 57-60, 2005
The Japanese Environmental Mutagen Society
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Details 詳細情報について
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- CRID
- 1390001204419645696
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- NII Article ID
- 130004476604
- 110001789604
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- NII Book ID
- AN1006217X
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- COI
- 1:CAS:528:DC%2BD2MXhtFWntLbN
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- ISSN
- 18807054
- 09100865
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- NDL BIB ID
- 7440720
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed