ミクリッツ病の新しい知見に基づく疾患概念

DOI

書誌事項

タイトル別名
  • Pathogenesis of salivary gland disease and xerostomia The conception of Mikulicz's disease based on new knowledge

抄録

This review focuses on two topics of salivary gland diseases regarding xerostomia. First, the pathogenesis and treatment of xerostomia after radiotherapy against head and neck cancer is discussed. It is well known that the extent of radiation-induced salivary dysfunction and mucositis depends on the radiation dose and field. Moreover, the balance in the defense system of oropharyngeal cavity alters after radiotherapy. This altered balance may impair the ability to maintain the stable immunological control mechanism. Second, the newly established concept about Mikulicz's disease is discussed. Recently, elevated IgG4 concentration in serum and prominent infiltrating by plasmacytes expressing IgG4 in the salivary glands in Mikulicz's disease were revealed. Mikulicz's disease is different from Sjögren's syndrome, and may be a systemic IgG4-related plasmacytic disease.

収録刊行物

  • 口腔・咽頭科

    口腔・咽頭科 19 (2), 241-248, 2007

    日本口腔・咽頭科学会

キーワード

詳細情報 詳細情報について

  • CRID
    1390001204425246208
  • NII論文ID
    130004161231
  • DOI
    10.14821/stomatopharyngology1989.19.241
  • ISSN
    18844316
    09175105
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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