Clinical investigation of malignant parotid tumors

DOI 3 Citations 13 References
  • Inamura Naoya
    Department of Otolaryngology, Head & Neck Surgery, Hokkaido University Graduate School of Medicine
  • Homma Akihiro
    Department of Otolaryngology, Head & Neck Surgery, Hokkaido University Graduate School of Medicine
  • Fukuda Satoshi
    Department of Otolaryngology, Head & Neck Surgery, Hokkaido University Graduate School of Medicine

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  • 当科における耳下腺悪性腫瘍症例の検討

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Abstract

We reviewed 55 cases of previously untreated malignant tumors arising in the parotid gland treated between Jan 1989 and May 2008.<br>Histopathologically, we observed 13 tumor types, the most frequent histological type being mucoepidermoid carcinoma (12), followed by adenoid cystic carcinoma (11). According to clinical stage, 5 subjects were classified as T1, 18 as T2, 10 as T3, and 22 as T4. N+cases numbered 7, and were staged as N2. Six had distant metastasis (5 lung and 1 axillary). Nineteen exhibited facial nerve palsy before treatment.<br>Among major therapies, surgery was conducted in 50 subjects, radiation therapy in 3, and chemotherapy, and percutaneous ethanol injection therapy in each.<br>Overall five-year survival determined using the Kaplan-Meier method was 73%. Among major histopathological types, five-year survival was 33% for undifferenciated carcinoma, 40% for adenocarcinoma, 62% for mucoepidermoid carcinoma, 67% for carcinoma in pleomorphic adenoma, and 100% for adenoid cystic carcinoma and acinic cell carcinoma. By T classification, five-year survival was 100% for T1, 88% for T2, 90% for T3, and 44% for T4. Five-year survival was 36% for those exhibiting facial nerve palsy and 94% for non palsy. Factors influencing poor outcome were T4 (p=0.001) and facial nerve palsy (p=0.001).

Journal

  • Stomato-pharyngology

    Stomato-pharyngology 22 (2), 167-172, 2009

    Japan Society of Stomato-pharyngology

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