Overfeeding induces protein catabolism and nutritional stress in critical ill patients.

DOI

Bibliographic Information

Other Title
  • 重症患者の栄養療法に起因する代謝性有害反応
  • エネルギーの過剰投与による筋タンパク異化と栄養ストレス

Abstract

Purpose: Overfeeding is known to induce metabolic problems in critical ill patients as well as malnutrition. In this study, we have determined the effect of overfeeding on protein catabolism as nutritional stress.<br>Subjects and Methods: Analyses were evaluated for metabolic status. 30 patients in a hospital ICU and receiving mechanical ventilation were measured energy expenditure by using indirect calorimetry. Patients were divided into 3 groups: underfeeding (U), adequate feeding (A), overfeeding (O). Energy expenditure, 3-methyl-histidine, creatinine, blood urea nitrogen, noradrenalin, C-reactive protein, prealbumin levels were assessed.<br>Results: The assessment of protein catabolism using 3-methyl-histidine/creatinine indicated that patients with overfeeding were prompt catabolism. BUN, CRP and prealbumin were not different among each group. The patients with overfeeding showed high level of urea noradrenalin significantly compared with other groups. However, length of ICU stay and ventilated duration were not changed between each group. Feeding routes; enteral nutrition, parental nutrition or both of those, did not make significant difference of protein catabolism and nutritional stress.<br>Conclusion: Overfeeding induced protein catabolism since it might be from nutrition stress.

Journal

  • Jomyaku Keicho Eiyo

    Jomyaku Keicho Eiyo 28 (6), 1251-1257, 2013

    Japanese Society for Parenteral and Enteral Nutrition

Keywords

Details 詳細情報について

  • CRID
    1390001204427337472
  • NII Article ID
    130004487331
  • DOI
    10.11244/jjspen.28.1251
  • ISSN
    18813623
    13444980
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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