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Can Intensive Lipid-Lowering Therapy with Statins Ameliorate Atherosclerosis in Japanese Patients?
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- Kurabayashi Masahiko
- Department of Medicine and Biological Science, Gunma University Graduate School of Medicine.
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- Sakuma Ichiro
- Hokko Memorial Clinic Caress Sapporo.
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- Kawamori Ryuzo
- Department of Medicine, Juntendo University School of Medicine.
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- Daida Hiroyuki
- Department of Cardiovascular Medicine, Juntendo University School of Medicine.
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- Yamazaki Tsutomu
- Department of Clinical Epidemiology & Systems, Graduate School of Medicine, University of Tokyo.
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- Yoshida Masayuki
- Life Science and Bioethics Research Center, Graduate School of Medicine, Tokyo Medical and Dental University.
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- Hata Mitsumasa
- Department of Cardiovascular Surgery, Nihon University School of Medicine.
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- Masuda Izuru
- Department of Internal Medicine, Higashiyama Takeda Hospital.
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- Kaku Kohei
- Division of Diabetes and Endocrinology, Department of Medicine, Kawasaki Medical School.
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- Yokoi Hiroyoshi
- Department of Cardiology, Kokura Memorial Hospital.
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- Kishimoto Junji
- Department of Digital Organ, Digital Medicine Initiative, Kyusyu University.
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- Nohara Ryuji
- Division of Cardiology, Kitano Hospital, Tazuke Kofukai Medical Research Institute.
Bibliographic Information
- Other Title
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- —Rationale and Design of the JART Study
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Description
Aim: In Japan, heart disease and cerebral ischemic disease are major causes of death. A decrease in the level of low-density lipoprotein cholesterol (LDL-C) through intensive treatment with statins positively correlates with a reduction in the volume of plaques in patients with cardiovascular disease. The METEOR trial, evaluating the effect of rosuvastatin on carotid intima-media thickness (IMT), was conducted only in Europe and the US. Here we planned another trial, the Justification for Atherosclerosis Regression Treatment (JART) study, to clarify the efficacy of intensive lipid-lowering therapy with rosuvastatin in Japanese with atherosclerosis.<BR>Methods and Results: Four hundred patients with hypercholesterolemia (LDL-C ≥140 mg/dL) and a maximum IMT of ≥1.1 mm will be treated for 24 months either with intensive lipid-lowering therapy with rosuvastatin (target LDL-C levels: 80 mg/dL for primary prevention, and 70 mg/dL for secondary prevention) or conventional lipid-lowering therapy with pravastatin (target LDL-C level: complying with JASGL2007). The primary endpoint will be the percent change of mean-IMT and the objectives of the study are to compare the two protocols.<BR>Conclusion: The JART trial is a prospective, randomized, open-label, blinded end-point evaluation, multi-center, parallel-group, comparative study to examine the regressive effect of intensive lipidlowering therapy with statins on atherosclerosis by evaluating IMT in the Japanese population.
Journal
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- Journal of Atherosclerosis and Thrombosis
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Journal of Atherosclerosis and Thrombosis 17 (4), 416-422, 2010
Japan Atherosclerosis Society
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Details 詳細情報について
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- CRID
- 1390001204431006720
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- NII Article ID
- 130004444437
- 50007681815
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- DOI
- 10.5551/jat.2899
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- COI
- 1:STN:280:DC%2BC3czhvFOmtA%3D%3D
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- ISSN
- 18803873
- 13403478
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- PubMed
- 20215710
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- JaLC
- Crossref
- PubMed
- CiNii Articles
- OpenAIRE
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- Abstract License Flag
- Disallowed
