Serum uric acid and mortality from cardiovascular disease: EPOCH-JAPAN study

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  • Zhang Wen
    Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine Department of Epidemiology, Fukushima Medical University
  • Iso Hiroyasu
    Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine
  • Murakami Yoshitaka
    Division of Medical Statistics, Department of Social Medicine, Faculty of Medicine, Toho University
  • Miura Katsuyuki
    Department of Public Health, Shiga University of Medical Science
  • Nagai Masato
    Department of Epidemiology, Fukushima Medical University
  • Sugiyama Daisuke
    Department of Preventive Medicine and Public Health, Keio University School of Medicine
  • Ueshima Hirotsugu
    Department of Public Health, Shiga University of Medical Science
  • Okamura Tomonori
    Department of Preventive Medicine and Public Health, Keio University School of Medicine
  • EPOCH-JAPAN GROUP

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  • Serum Uric Acid and Mortality Form Cardiovascular Disease: EPOCH-JAPAN Study

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Aim: To investigate the relationship between serum uric acid levels and cardiovascular disease in Asians. <br>Methods: We examined the above relationship using the data of Evidence for Cardiovascular Prevention from Observational Cohorts in Japan (EPOCH-JAPAN Study). The data of 36,313 subjects (15,628 men and 20,685 women aged 35–89 years without histories of stroke, coronary heart disease, or cancer at baseline) were used for the analyses. <br>Sex-specific hazard ratios (HRs) of mortality from cardiovascular disease were estimated according to the quintiles of serum uric acid using Cox hazard models stratified by cohorts. <br>Results: During 441,771 person-years of follow-up, we documented 1,288 cardiovascular deaths. A J- or U-shaped relationship between serum uric acid level and cardiovascular disease mortality was observed. Compared with the lowest quintile of serum uric acid levels, the highest quintile was associated with an increased cardiovascular disease mortality in men [HR: 1.28; 95% confidence interval (CI): 1.01–1.63] and women (HR: 1.51; 95% CI: 1.14–1.99). However, there was no significant association with mortality from stroke, coronary heart disease or heart failure in both men and women. <br>Conclusion: This large pooled analysis in Japan suggested a J- or U-shaped relationship between serum uric acid levels and cardiovascular mortality. The highest quintile of serum uric acid levels was associated with increased cardiovascular disease mortality in both Japanese men and women.

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