Associations of Cardiovascular Risk Factors with Carotid Intima-Media Thickness in Middle-Age Adults and Elders
-
- Wu Tzu-Wei
- Department of Medicine, Mackay Medical College
-
- Hung Chung-Lieh
- Section of Cardiology, Department of Internal Medicine, Mackay Memorial Hospital, Mackay Medical College
-
- Liu Chun-Chieh
- Section of Cardiology, Department of Internal Medicine, Mackay Memorial Hospital, Mackay Medical College
-
- Wu Yih-Jer
- Department of Medicine, Mackay Medical College Section of Cardiology, Department of Internal Medicine, Mackay Memorial Hospital, Mackay Medical College Institute of Biomedical Sciences, Mackay Medical College
-
- Wang Li-Yu
- Department of Medicine, Mackay Medical College Institute of Biomedical Sciences, Mackay Medical College
-
- Yeh Hung-I
- Department of Medicine, Mackay Medical College Section of Cardiology, Department of Internal Medicine, Mackay Memorial Hospital, Mackay Medical College Institute of Biomedical Sciences, Mackay Medical College
この論文をさがす
説明
<p>Aims: Elevated carotid intima-media thickness (cIMT) is a preclinical phenotype of atherosclerotic diseases. There are significant sex differences in the morbidities of cardiovascular diseases and their major determinants, and we explored the sex-specific effects of cardiovascular factors on cIMT by a community-based study.</p><p>Methods: We measured the cIMT and cardiovascular profiles of 1579 residents aged 40–74 years in northern Taiwan. Multivariate regression analyses were used to assess the effects and contributions of these factors on cIMT.</p><p>Results: Males had significantly higher mean (±SD) of cIMT than females (0.668±0.113 vs. 0.632± 0.100 nm, p＜0.0001). The common factors of the best-fit regression models in both sexes were age, BMI, and LDL-/HDL-C ratio; however, their contributions and effects were different. The partial coefficients of determination (r2) were 17.9, 5.8, and 4.1%, respectively, for males and were 27.8, 1.4, and 1.2%, respectively, for females. Test statistics showed that the regression coefficients of BMI and LDL-/HDL-C ratio of males were significantly higher than those of females. As compared with females, per 1.0 SD increases of BMI and LDL-/HDL-C in males resulted in 0.0971 (p=0.030) and 0.1177 (p=0.0087), respectively, SD increases in cIMT. There was no difference in the means of cIMT between pre- and post-menopausal women of the same age groups.</p><p>Conclusions: There was a significant sex difference in cIMT. The contributions and effects of LDL-/HDL-C ratio and BMI on cIMT were more profound in males. Our findings indicate that sex-specific factors, but possibly not menstrual status-related factors, contribute to thicker cIMT.</p>
収録刊行物
-
- Ｊｏｕｒｎａｌ ｏｆ Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ ａｎｄ Ｔｈｒｏｍｂｏｓｉｓ
-
Ｊｏｕｒｎａｌ ｏｆ Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ ａｎｄ Ｔｈｒｏｍｂｏｓｉｓ 24 (7), 677-686, 2017
一般社団法人 日本動脈硬化学会
