書誌事項
- タイトル別名
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- The framework of health risk evaluation for hazardous chemicals: proposals for new challenges
- ユウガイ カガク ブッシツ ニ ヨル ケンコウ リスク ヒョウカ ソノ ゲンジョウ ト ショウライ
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抄録
The health risk due to the exposure to hazardous chemicals in the environment has been traditionally evaluated mainly based on the dose-response relationship determined for human, including the relationship of test animals with appropriate safety factor. However our daily life faces to so many varieties of hazardous chemicals that have not enough toxicity information for health risk evaluation. Here, a new challenge for health risk evaluation framework is proposed to reinforce the traditional framework with the sequential three models: (1) the PBPK model to convert the external exposure dose of chemicals into the internal dose in the target organ/tissue, (2) the dose-response relationship determined at cellular level of the target organ/tissue, and (3) the adverse effect-developing model to convert the change in cellular level into the somatic health risk, e. g., a mathematical cancer model. The expected contribution and utilities of the new framework are also discussed together with the modified framework to use the radiation equivalent dose of chemicals. <br>The new framework, combined with the traditional, is highly expected as an effective and comprehensive health risk evaluation framework especially for new hazardous chemicals in our living environment.
収録刊行物
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- 日本リスク研究学会誌
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日本リスク研究学会誌 20 (2), 115-123, 2010
一般社団法人日本リスク学会
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詳細情報 詳細情報について
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- CRID
- 1390001204431422592
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- NII論文ID
- 130004845584
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- NII書誌ID
- AN10490730
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- ISSN
- 21854548
- 09155465
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- NDL書誌ID
- 10805855
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可