Expression of p53-Regulated Genes in Cultured Mammalian Cells After Exposure to A Space Environment
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- Ohnishi Takeo
- Department of Biology, School of Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan
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- Takahashi Akihisa
- Department of Biology, School of Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan
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- Suzuki Hiromi
- Japan Space Forum, 2-2-1 Ohtemachi, Chiyoda-ku, Tokyo 104-0004, Japan
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- Omori Katsunori
- Japan Aerospace Exploration Agency, 2-1-1 Sengen, Tsukuba, Ibaraki 305-8505, Japan
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- Shimazu Toru
- Japan Space Forum, 2-2-1 Ohtemachi, Chiyoda-ku, Tokyo 104-0004, Japan
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- Ishioka Noriaki
- Japan Aerospace Exploration Agency, 2-1-1 Sengen, Tsukuba, Ibaraki 305-8505, Japan
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抄録
The space environment contains two major biologically significant influences; space radiation and microgravity. The tumor suppressor gene product p53 is generally thought to contribute to the genetic stability of cells with DNA damage through the activity of p53 initiated signal transduction pathways. We propose to investigate the expression of p53-regulated genes in cultured mammalian cells after exposure to a space environment. We expect that the data from this proposal will be useful for designing physiological protection against the serious effects of space radiation during long-term stays in space.
収録刊行物
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- Biological Sciences in Space
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Biological Sciences in Space 23 (1), 3-9, 2009
日本宇宙生物科学会
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詳細情報 詳細情報について
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- CRID
- 1390001204431443712
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- NII論文ID
- 130004450594
- 10025115182
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- NII書誌ID
- AN10164806
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- DOI
- 10.2187/bss.23.3
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- ISSN
- 1349967X
- 09149201
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- NDL書誌ID
- 10364013
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- 抄録ライセンスフラグ
- 使用不可