Introduction to The Proposed Space Experiments Aboard The ISS Using The Silkworm, Bombyx mori

DOI Web Site 参考文献27件 オープンアクセス
  • Furusawa Toshiharu
    Center for Bioresource Field Science, Kyoto Institute of Technology, Ipponki-chou, Ukyou-ku, 616-8354 Kyoto, Japan
  • Nojima Kumie
    National Institute of Radiological Sciences, Inage, Chiba 263-8555, Japan
  • Ichida Masatoshi
    Center for Bioresource Field Science, Kyoto Institute of Technology, Ipponki-chou, Ukyou-ku, 616-8354 Kyoto, Japan
  • Nagaoka Sumiharu
    Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan
  • Sugimura Yukio
    Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan
  • Suzuki Eiko
    Center for Bioresource Field Science, Kyoto Institute of Technology, Ipponki-chou, Ukyou-ku, 616-8354 Kyoto, Japan
  • Sumida Motoyuki
    Center for Bioresource Field Science, Kyoto Institute of Technology, Ipponki-chou, Ukyou-ku, 616-8354 Kyoto, Japan
  • Suzuki Hiromi
    Department of Space Environmental Medicine, Graduate School of Medical and Dental Science, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima-shi, Kagoshima 890-8544, Japan Technology and Research Promotion Department, Japan Space Forum, Shin-Otemachi Bldg. 7F, 2-2-1 Otemachi, Chiyoda-ku, Tokyo 100-0004, Japan.
  • Simazu Toru
    Technology and Research Promotion Department, Japan Space Forum, Shin-Otemachi Bldg. 7F, 2-2-1 Otemachi, Chiyoda-ku, Tokyo 100-0004, Japan.
  • Omori Katsunori
    Japan Aerospace Exploration Agency, Tsukuba, Ibaraki 305-8505, Japan
  • Ishioka Noriaki
    Department of Space Environmental Medicine, Graduate School of Medical and Dental Science, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima-shi, Kagoshima 890-8544, Japan Japan Aerospace Exploration Agency, Tsukuba, Ibaraki 305-8505, Japan
  • Fujii Hiroshi
    Institute of Genetic Resources, Kyushu University, Hakozaki Higashi-ku Fukuoka 812-8581, Japan
  • Nagaoka Shunji
    School of Health Science, Fujita Health University, Toyoake, Aichi 470-110, Japan

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説明

The authors have a plan to examine the biological effects of cosmic rays by loading the eggs of the silkworm, Bombyx mori, in the International Space Station (ISS) for 3 months. In advance of the project, several ground experiments have been performed. In order to investigate the biological effects of radiation, heavy ion particles were used instead of cosmic rays. Heterozygous eggs of the black-striped strain (pS/p) were irradiated with Carbon (C), Neon (Ne) or Ferrous (Fe) ion particles. At the fifth instar stage, larvae that hatched from these eggs showed white spots on their backs against the black or dark brown of their integument. These are somatic mutations which seem to be caused by the effects of radiation on the pS gene. The incidence of this somatic mutation increased in proportion to dose and linear energy transfer of C and Ne ion particles, and it was higher after resumption of embryogenesis in eggs that had been irradiated after diapause termination as compared with eggs irradiated while still in diapause. Irradiation by more than 0.04 Gy of Fe ion particles to diapause-terminated eggs induced a significant incidence of somatic mutation compared with controls (P<0.05). Furthermore, radiation effects were also detected at the next generation as detected by egg color mutations by using the specific locus method. In experiments investigating the effects of microgravity on silkworm embryogenesis in the US Space Shuttle/Atlantis (STS-84) in 1997, we had observed that microgravity could influence embryonic reversal, presumably resulting in abnormal development of embryos. On the basis of the results from STS-84 flight and the above mentioned ground experiments, the authors will examine the interrelationship between the dose of cosmic rays and the incidence of somatic mutation, as well as confirm and extend the analysis of synergistic effects between cosmic rays and microgravity on mutation rates in experiments conducted using the ISS. These data will provide fundamental information on the effects of cosmic rays on biological systems that can then be applied to better protect humans against cosmic radiation during space flight.

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