Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Plays an Important Role in Vascular Inflammation in Current Smokers
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- Takanabe-Mori Rieko
- Division of Translational Research, National Hospital Organization Kyoto Medical Center.
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- Ono Koh
- Division of Translational Research, National Hospital Organization Kyoto Medical Center. Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University.
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- Wada Hiromichi
- Division of Translational Research, National Hospital Organization Kyoto Medical Center.
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- Takaya Tomohide
- Department of Vascular Physiology, National Cerebral and Cardiovascular Center Research Institute.
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- Ura Shuichi
- Division of Translational Research, National Hospital Organization Kyoto Medical Center.
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- Yamakage Hajime
- Clinical Research Institute, National Hospital Organization Kyoto Medical Center.
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- Satoh-Asahara Noriko
- Clinical Research Institute, National Hospital Organization Kyoto Medical Center.
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- Shimatsu Akira
- Clinical Research Institute, National Hospital Organization Kyoto Medical Center.
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- Takahashi Yuko
- Health Administration Center, Nara Women’s University.
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- Fujita Masatoshi
- Department of Cardiovascular Medicine, Uji Hospital.
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- Fujita Yoshiko
- Department of Vascular Physiology, National Cerebral and Cardiovascular Center Research Institute.
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- Sawamura Tatsuya
- Department of Vascular Physiology, National Cerebral and Cardiovascular Center Research Institute.
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- Hasegawa Koji
- Division of Translational Research, National Hospital Organization Kyoto Medical Center.
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Aim: Smoking induces vascular inflammation and increases the risk of cardiovascular events. Lectinlike oxidized low-density lipoprotein receptor-1 (LOX-1) is a scavenger receptor that is induced by oxidative stress and is associated with atherosclerotic plaque formation and destabilization. LOX-1 interacts with C-reactive protein (CRP) and plays an important role in inflammatory diseases. We therefore hypothesized that LOX-1 may be involved in the onset of smoking-induced vascular inflammation.<BR>Methods: We measured the soluble LOX-1 (sLOX-1) levels in sera obtained from 207 current smokers.<BR>Results: The serum sLOX-1 levels positively correlated with various smoking variables, such as the number of cigarettes smoked per day (r= 0.150, p<0.05), the expired air carbon monoxide (CO) concentrations (r= 0.198, p<0.005) and the Fagerstrom test for nicotine dependence scores (r= 0.190, p<0.01). The serum levels of sLOX-1 also correlated with those of a representative inflammatory marker, the serum high-sensitivity CRP level (hsCRP; r= 0.232, p<0.005). A multivariate regression analysis revealed the independent determinants of the serum sLOX-1 level to be the expired air CO concentration (β= 0.182, p<0.05) and the hsCRP level (β= 0.213, p<0.01).<BR>Conclusions: The serum sLOX-1 level was found to increase in close association with both the smoking-related variables and the inflammatory marker hsCRP. These findings suggest that LOX-1 may therefore play an important role in the onset of smoking-induced inflammation and atherosclerosis in humans.
収録刊行物
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- Ｊｏｕｒｎａｌ ｏｆ Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ ａｎｄ Ｔｈｒｏｍｂｏｓｉｓ
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Ｊｏｕｒｎａｌ ｏｆ Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ ａｎｄ Ｔｈｒｏｍｂｏｓｉｓ 20 (6), 585-590, 2013
一般社団法人 日本動脈硬化学会