書誌事項
- タイトル別名
-
- Risk assessment for benzene induced leukemia based on a chromosome aberration test using CD34<SUP>+</SUP> cells
- CD34[+]細胞の染色体異常試験に基づいたベンゼン誘発白血病のリスク評価
- CD34 サイボウ ノ センショクタイ イジョウ シケン ニ モトズイタ ベンゼン ユウハツ ハッケツビョウ ノ リスク ヒョウカ
この論文をさがす
抄録
Risk assessment system for radiation has been well developed, so defining the radiation equivalent dose for chemical agents could place in the order of their risk. As well as the radiation, benzene causes leukemia to humans. Therefore, we evaluated the radiation equivalent dose for benzene based on its metabolites and low-dose rate radiation induced chromosome aberrations using CD34+ cells from human bone marrow, which is the target organ of benzene induced leukemia. As a result, we got leukemia estimates which were about thirtieth part of those evaluated by U.S.EPA based on epidemiological data. We need to accumulate much more studies in order to validate this framework, but it could be effectual as an alternative risk assessment with few animal studies.
収録刊行物
-
- 日本リスク研究学会誌
-
日本リスク研究学会誌 20 (4), 267-277, 2010
一般社団法人日本リスク学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390001204432923136
-
- NII論文ID
- 130004845590
-
- NII書誌ID
- AN10490730
-
- ISSN
- 21854548
- 09155465
-
- NDL書誌ID
- 10996299
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可