[Updated on Apr. 18] Integration of CiNii Articles into CiNii Research

Spherical Embolic Agents for Liver Tumor Embolization

DOI
  • Osuga Keigo
    Department of Diagnostic and Interventional Radiology, Osaka University Graduate School of Medicine
  • Maeda Noboru
    Department of Diagnostic and Interventional Radiology, Osaka University Graduate School of Medicine
  • Higashihara Hiroki
    Department of Diagnostic and Interventional Radiology, Osaka University Graduate School of Medicine
  • Tanaka Kaishu
    Department of Diagnostic and Interventional Radiology, Osaka University Graduate School of Medicine
  • Kishimoto Kentaro
    Department of Diagnostic and Interventional Radiology, Osaka University Graduate School of Medicine
  • Nakamura Masahisa
    Department of Diagnostic and Interventional Radiology, Osaka University Graduate School of Medicine
  • Ono Yusuke
    Department of Diagnostic and Interventional Radiology, Osaka University Graduate School of Medicine
  • Nakazawa Tetsuro
    Department of Diagnostic Radiology, Osaka Medical Center for Cancer and Cardiovascular Diseases
  • Tomiyama Noriyuki
    Department of Diagnostic and Interventional Radiology, Osaka University Graduate School of Medicine

Bibliographic Information

Other Title
  • 肝動脈塞栓療法における球状塞栓物質

Abstract

Recently, three products of calibrated microspheres (Embosphere®, HepaSphere®, and DC-Bead®) have been approved in Japan as embolic agents for hypervascular tumors and arteriovenous malformations. The advantages of these microspheres are that the particles are uniform in size, and easy to inject through a microcatheter. They can travel distally to vessels corresponding to the particle size, and thus, the occlusion level is predictable. Worldwide, the use of these microspheres has been already prevalent in chemoembolization or bland embolization of hepatocellular carcinoma. Two of the approved microspheres (DC-Bead® and HepaSphere®) are also applied as drug-eluting microspheres. However, operators should pay attention to some pitfalls in the use of microspheres. Temporary aggregation and redistribution of microspheres may restore the blood flow of a once occluded vessel. The mechanical properties of drug eluting microspheres may alter upon drug loading and release. Therefore, we need to understand the behavior of each microsphere to obtain the optimal embolic effects. It is also important to investigate the true benefits of microspheres or in what clinical or pathological conditions they will improve the safety and efficacy compared to conventional materials.

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Details

  • CRID
    1390001204435149056
  • NII Article ID
    130004707480
  • DOI
    10.11407/ivr.28.427
  • ISSN
    2185-6451
    1340-4520
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
    • KAKEN

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