集束超音波を利用したマイクロバブルの二次元マニピュレーション

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  • 松崎 玄伸
    東京大学大学院工学系研究科機械工学専攻
  • 尾崎 太一
    東京大学大学院工学系研究科機械工学専攻
  • 井上 和仁
    東京大学大学院工学系研究科機械工学専攻
  • 東 隆
    東京大学大学院医学系研究科疾患生命工学センター
  • 一柳 満久
    上智大学理工学部機能創造理工学科
  • 松本 洋一郎
    東京大学大学院工学系研究科機械工学専攻
  • 高木 周
    東京大学大学院工学系研究科機械工学専攻

書誌事項

タイトル別名
  • Two-Dimensional Microbubble Manipulation by Mechanically Controlled Ultrasound Focus
  • シュウソク チョウオンパ オ リヨウ シタ マイクロバブル ノ ニジゲン マニピュレーション

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説明

<p>Microbubbles (MB) are widely used as contrast agents in ultrasound diagnostic imaging because of its surpassing responsiveness to several MHz band. Recently, many researchers are trying to apply MB and ultrasound to drug delivery system (DDS) using MB as drug carrier or gene transfer. For clinical application of MB-DDS, it is crucial to manipulate microbubbles contactlessly, capture in a desired place, and destruct them near the target. In this research, we developed a promising method to capture and manipulate Sonazoid using a concave transducer which radiates focused ultrasound. We used concave transducers, witch calibers were 40 mm and focal distances were 40 mm. The center of the transducers was made a 20-mm diameter hole in to allow observation light to pass through. We found that MB in focused ultrasound field can manipulate moving ultrasound focus mechanically, it is mainly the effect of primary Bjerknes force. The accuracy of the two-dimensional manipulation was 10 μm order. The manipulation force by primary Bjerknes force was 6 pN in 5.46 MHz, 4 kPa ultrasound conditions. The accuracy of the manipulation is sufficiently better compared to the focal width radiated by the concave transducer. When estimating trapping force near a bubble cluster formed at the focal region, secondary Bjerknes force is mainly acting on MBs in 10 μm order distance.</p>

収録刊行物

  • 混相流

    混相流 32 (1), 108-115, 2018-03-15

    日本混相流学会

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